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A tale of two colleges
COVID-19 at the University of Wisconsin this fall has been pretty much a non-issue. While we are wearing masks, full in-person teaching is happening on campus. Bars, restaurants, and all other busine…
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Get your Vitamin D to Protect Yourself from COVID-19
This sounds like another hydroxychloroquine or ivermectin hoax, but the science is peer-reviewed. Getting enough vitamin D in your diet is an excellent way to protect yourself from severe COVID-19. E…
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About 35,000 people die from drug-resistant infection in the US. What are we going to do?
When antibiotics first achieved widescale use in the middle of the 20th century, they had a tremendous impact. For example, the mortality rate in England from infectious disease dropped from 25% in 1…
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Nasal nanoSTING vaccines may Provide Lasting Protection Against SARS-CoV-2
All successful vaccines against SARS-CoV-2 have used the spike protein as the target and delivered the vaccine by intramuscular injection, typically a shot in the left or right shoulder. The vaccines…
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Probiotic Bacterium can prevent antibiotic use side effects
Researchers at the University of Maryland School of Medicine demonstrate the power of probiotics. A test group was given Bifidobacterium lactis BB-12 as they took a course of amoxicillin clavula…
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News

Finally, a potentially powerful treatment for COVID-19


 

At the present time, there are no blockbuster drugs that dramatically improve the outcome of patients infected with SARS-CoV-2. While remdesivir and steroids do improve time to recovery and mortality, neither reverse the course of disease in most patients, especially if the patient has waited too long to go to the hospital. One promising area of research is antibody treatments, where antibodies are created that attack the spike protein of SARS-CoV-2 and label it for destruction. The problem with these treatments is that they are expensive, heat-labile, and do not scale well.

 

Recently, Göttingen researchers have developed mini-antibodies, derived from alpacas, that solve all of these drawbacks. They bind extremely tightly to the spike protein, are cheaper to produce, can be made in large quantities, and are stable up to 95°C (that is close to the temperature of boiling water). Their heat stability is especially useful as it makes it much easier to distribute and administer the antibodies. Their new drug is about to enter clinical trials and here is hoping that it turns out to be a powerful weapon against SARS-CoV-2.