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Microbiology stands on the shoulders of chemistry, physics, mathematics, and many other areas of study. To be able to talk the language of microbiology, there is an entrance fee in the form of a basic set of knowledge you must acquire from these other disciplines. In this chapter, we cover many important concepts that a student of microbiology needs as a foundation for the rest of microbiology. These bases concepts are probably a review for many, but you may want to read it anyway because it might give you a new perspective on the knowledge you already have.